Treated by Dr. Kavya Jonnalagadda at Sree Charith Hospital
Cushing's disease occurs when a benign tumour in the pituitary gland releases too much ACTH (adrenocorticotropic hormone), causing the adrenal glands to produce excess cortisol. This hormone imbalance affects many body systems over time. Dr Kavya Jonnalagadda provides comprehensive assessment and individualised treatment to help manage this condition.
A small benign tumour less than 10mm in size within the pituitary gland, accounting for most cases of Cushing's disease
A larger benign tumour greater than 10mm that may cause additional symptoms from mass effect on surrounding structures
Return of excess cortisol production after initial successful treatment, requiring further evaluation and management
Multiple factors can contribute to the development and progression of this condition.
Recognising the signs early gives you more treatment options.
Diagnosis begins with a detailed medical history and physical examination to identify characteristic features. Laboratory tests confirm excess cortisol production and help locate its source. Not every patient requires all investigations; testing is selected based on individual findings.
From conservative to surgical — we always start with the least invasive option first.
A structured, patient-first approach from first visit to full recovery.
Sree Charith Hospital begins with a thorough clinical evaluation, reviewing your symptoms, medical history and any previous investigations to understand your individual situation
We arrange the necessary blood and urine tests to confirm excess cortisol production and identify its source, followed by imaging studies to locate any pituitary abnormality
Based on test results, tumour characteristics and your overall health, we develop an individualised management plan that may include referral for surgery, medical therapy or a combination approach
After treatment, we provide ongoing follow-up to monitor hormone levels, manage any replacement therapy, watch for recurrence and address complications such as diabetes or bone health
What to expect at each phase of recovery.
Initial weeks focus on monitoring cortisol levels and managing the transition from excess to normal or low cortisol, which may require temporary steroid replacement and close observation
Over several months, blood pressure, blood sugar and weight gradually improve as cortisol levels normalise, though individual timelines vary and some changes may persist
Ongoing assessment continues for years to detect any recurrence, optimise hormone replacement if needed and manage long-term effects on bones, heart and metabolism
Successful treatment aims to restore normal cortisol levels, which may improve blood pressure, blood sugar control and metabolic health, though individual responses vary
Many physical changes such as weight gain, skin thinning and muscle weakness may gradually improve, but some features like stretch marks and bone loss may not fully reverse
Some patients require lifelong hormone replacement or continued monitoring for recurrence, making regular endocrine follow-up an important part of long-term health
Treatment focuses on addressing complications such as diabetes, osteoporosis and cardiovascular effects that may have developed during the period of excess cortisol
Untreated Cushing's disease leads to progressive worsening of high blood pressure, diabetes and cardiovascular disease, significantly increasing the risk of heart attack and stroke. Continued excess cortisol weakens bones, raising fracture risk, and suppresses the immune system, making infections more likely. Quality of life declines due to severe muscle weakness, mood disturbances and physical changes.
Seek medical evaluation if you notice unexplained weight gain concentrated in the face and trunk, easy bruising, persistent fatigue or muscle weakness that affects daily activities. Early assessment is important if you develop high blood pressure or diabetes that is difficult to control, especially when combined with characteristic physical changes. Prompt diagnosis and treatment help prevent serious complications.
Early treatment means more options and better outcomes. Book a consultation to understand your condition and explore the right path forward.
